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Friday, 04 April 2014

Protein Spotlight Update: on the garden pea

The life sciences owe a lot to green peas. And perhaps even to the bishop of St Thomas Abbey in Brno – now the Czech Republic. It was there, in the 1850s, that Gregor Johann Mendel (1822-1884) decided to undertake studies on heredity using mice. The bishop, however, disagreed with research involving animal sex, so his friar turned to the more innocent garden pea. Mendel spent the best part of a decade cross-breeding peas, while considering seven different phenotypic traits that seemed – t... More

Monday, 24 March 2014

SIB Profile 2013 - A look at our institute

The SIB Annual Report 2013, now called SIB Profile 2013 - A look at our institute, is out!More More

Wednesday, 12 March 2014

Joint Summer School on Systems medicine

The SIB and are organising a Joint Summer School on Systems medicine and its applications in June 22-27, 2014 in Kandersteg, a small and charming village in the Swiss Alps. More More

Thursday, 06 March 2014

Protein Spotlight Update: a gut's tale

Many of our cells are not…us… Besides the cells we produce, we carry around an awful lot of bacteria. In reality, 90 percent of the cells that make us up are bacterial, that is to say about one billion billion. That’s a lot. A large proportion of these bacteria are part of our gut, add an average of 2 kg to our adult weight and form what has been termed our gut microbiome. Why have they set up camp inside us? Because we need them… And vice versa. The human gut hosts bacteria that are ... More

Tuesday, 25 February 2014

Augmenting genomics through metabolomics

The field of genomics has opened up new perspectives to determine the origins of various phenotypes, such as diseases and physiological traits. Statistical studies that measure correlations between genetic and phenotypic variations within large populations have provided important results, but, so far, have explained only a small fraction of heritability. To address this issue, Rico Rueedi, Prof. Zoltán Kutalik, and Prof. Sven Bergmann of the University of Lausanne investigate, in the contex... More

Monday, 24 February 2014

„Microbial Pompeji“ in dental calculus

Researchers of the University of Zurich have discovered a „microbial Pompeii“ preserved on the teeth of skeletons around 1,000 years old. They found a high concentration of genetic material, as well as numerous opportunistic pathogens and could establish that periodontal disease is caused by the same bacteria today as in the past. More More

Friday, 21 February 2014

Elucider la génomique grâce aux métabolites - IN FRENCH

La génomique a ouvert des perspectives inédites pour percer l'origine des divers phénotypes tels que maladies ou traits physiologiques. Si un nombre important des résultats en génomique provient d'études statistiques qui mesurent les corrélations entre variations génétiques et phénotypiques au sein de grands groupes d'individus, celles-ci n'expliquent qu'une petite fraction de l'héritabilité. Pour pallier ce manque, Rico Rueedi, Zoltán Kutalik et le Prof. Sven Bergmann proposent,... More

Tuesday, 11 February 2014

Automated quantitative histology reveals vascular morphodynamics during Arabidopsis hypocotyl secondary growth

Prof. Christian Hardtke, Director of the Department of Plant Biology at the University of Lausanne, with the help of SIB’s High Performance Computing Group led by Ioannis Xenarios, established an “Automated Quantitative Histology” approach to analyze high-resolution images of hypocotyl cross-sections in an automated manner. The approach, funded by, combines high-resolution imaging with automated image segmentation and supervised machine learning to achieve accurate cellular ... More

Thursday, 30 January 2014

Protein Spotlight Update: a pain soothed

Pain is part of an animal’s life. It is there to tell us that something is wrong, and needs to be attended to. There is moral pain. And physical pain, the more definable of the two, which serves two purposes. The first, to warn us of tissue damage and, more often than not, its localisation. The second, to understand where danger lies, so as to avoid it in the future. Unless, of course, it has been lethal. Ever since Life emerged, Nature has been using pain as a means of communication. Thoug... More

Thursday, 30 January 2014

Henrik Kaessmann – awarded ERC Consolidator Grant of 2 million euros

Henrik Kaessmann, Leader of SIB Group Functional Evolutionary Genomics, has just been awarded a prestigious European Research Council (ERC) Consolidator Grant worth 2 million euros, as a follow-up on his previous ERC Starting Grant in 2010, to carry out research on ontogenetic transcriptome evolution in tetrapods.Kaessmann is one of 312 top scientists – out of 3600 proposals – to have been selected by the European Research Council in its first Consolidator Grant competition. The grants ar... More

Sunday, 19 January 2014

Biology’s “dark matter”

Thanks to bioinformatics, researchers from the University of Lausanne have shed light upon a poorly understood category of genes, which produce long non-coding RNA molecules rather than proteins. A few of these genes appeared over 350 million years ago in the common ancestor of 11 species – amongst which humans, the great apes, opossums and frogs. The article was published in Nature, on 19 January 2014.More More

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