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Simon Bernèche
Computational Biophysics Group
University of Basel
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At the Computational Biophysics Group we are interested in the structure-function relationship of membrane proteins. Using molecular mechanics simulations and statistical approaches, our group aims at understanding the microscopic mechanisms underlying the functions of proteins involved in the membrane transport of various substrates to discover how the functions of proteins emerge from their 3D structure. A central topic of study concerns the elucidation of gating mechanisms regulating ion permeation and the activity of potassium channels in excitable cells, and the resulting impact on neuron signalling. Other subjects of interest involve transport mechanisms that are ATP-dependent or proton-coupled, and the mechanisms of protein folding.

Our research topics: